Histone modifications can be altered by different environmental stimuli and may provide a “memory” of previous transcription or activation. While the role of the many histone modifications discovered thus far has not yet been established, many modifications have been associated with specific transcriptional states. Are epigenetic modifications heritable? Epigenetic heritabilityRead More →
This histone fold provides the basic unit of DNA packaging in eukaryotic cells. Outside of the region of the histone fold, the N-terminus of the histone forms a ‘tail’ comprising between 20 and 40 amino acids and having no defined secondary structure. Why do histones proteins contain lysine and arginine?Read More →
Lysine acetylation can generate highly charged enzymes with increased resistance toward irreversible inactivation. Does histone acetylation increase with age? Epigenetic marks such as the acetylation of histones change substantially when animals age. … As animals age, the control of gene expression, which is orchestrated by multiple epigenetic factors, degenerates. InRead More →